We present a yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the modes of action of compounds. We developed a ...

Owing to reiterative use of domains by iPKSs, co-linearity rule of modular type I PKSs is not applicable to assume iPKS function. 6 We have been working on expression of fungal iPKSs and product ...

Vitamin B 12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in ...