Nature

Deletion and Insertion Mutations in Short Tandem Repeats in the Coding Regions of Human Genes

In vitro studies in bacterial, yeast and eukaryotic systems have demonstrated the existence of deletion and insertion ‘hotspots’ involving repetitive sequences. Slipped-strand mispairing (SSM) has ...
Nature

A large deletion in the CFTR gene in CBAVD

Purpose: Most cystic fibrosis mutation screening methods do not detect large exon deletions or duplications in the cystic fibrosis transmembrane regulator gene. We looked for such mutations in ...
ascopubs.org

Deletion and mutation of IL10RA gene on chromosome 11q23 to avert CpG-B oligodeoxynucleotides-induced apoptosis of human chronic lymphocytic leukemia B cells.

A phase I open-label study of Ad-RTS-hIL-12, an adenoviral vector engineered to express hIL-12 under the control of an oral activator ligand, in subjects with unresectable stage III/IV melanoma.
News Medical

Deletion Mapping Explained

Deletion mapping allows geneticists to answer several questions about a specific gene. It can determine where a deleted region of a gene is located, whether this deletion affects only the area in ...
News Medical

H69/V70 deletion in Alpha variant enables SARS-CoV-2 to overcome chinks in its armor

One of the key mutations seen in the 'Alpha variant' of SARS-CoV-2 - the deletion of two amino acids, H69/V70 - enables the virus to overcome chinks in its armor as it evolves, say an international ...
ascopubs.org

EGFR Inhibitors Plus Bevacizumab are Superior Than EGFR Inhibitors Alone as First-Line Setting in Advanced NSCLC With EGFR Mutations and BIM Deletion Polymorphisms (BIM-CLICaP)

Tumor-Infiltrating Lymphocytes, Tumor Mutational Burden, and Genetic Alterations in Microsatellite Unstable, Microsatellite Stable, or Mutant POLE/POLD1 Colon Cancer A retrospective analysis was ...